CVE-2026-31964
While most alignment records store DNA sequence and quality values, the format also allows them to omit this data in certain cases to save space.
Does this matter?
Lower severity and a low EPSS score (0.32%). Track it; it rarely justifies an emergency change on its own.
Description
HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data using a variety of encodings and compression methods. While most alignment records store DNA sequence and quality values, the format also allows them to omit this data in certain cases to save space. Due to some quirks of the CRAM format, it is necessary to handle these records carefully as they will actually store data that needs to be consumed and then discarded. Unfortunately the `CONST`, `XPACK` and `XRLE` encodings did not properly implement the interface needed to do this. Trying to decode records with omitted sequence or quality data using these encodings would result in an attempt to write to a NULL pointer. Exploiting this bug causes a NULL pointer dereference. Typically this will cause the program to crash. Versions 1.23.1, 1.22.2 and 1.21.1 include fixes for this issue. There is no workaround for this issue.
- CVSS 4.0
- 6.9 MEDIUMCVSS:4.0/AV:N/AC:L/AT:N/PR:N/UI:N/VC:N/VI:L/VA:L/SC:N/SI:N/SA:N/E:X/CR:X/IR:X/AR:X/MAV:X/MAC:X/MAT:X/MPR:X/MUI:X/MVC:X/M
- EPSS
- 0.32% probability · 25th percentile
- CISA KEV
- Not listed
- Weakness
- CWE-476
- Affected
- htslib/htslib
- Source
- security-advisories@github.com
References
Source: NVD record, EPSS from FIRST.org, KEV from CISA. Refreshed daily.